Home

Common variable immunodeficiency wiki

Common variable immunodeficiency (CVID) is a heterogeneous immune disorder characterized by recurrent sinopulmonary infections, autoimmune diseases, and granulomatous disease. A phenotypic approach to classify CVID has been suggested, based upon the type of complications the patient demonstrates. Five phenotypic categories were proposed Common variable immunodeficiency, abbreviated CVID, is a group of genetic disorders characterized by deficient antibody production Common variable immunodeficiency disease or CVID is a group of about 150 immunodeficiency disorders that are all characterized by low levels of all three types of immunoglobulin in the blood and the lack of any other underlying condition. The disease can be caused by a number of different causes, many of which are genetic in origin Common variable immunodeficiency (in abbreviation CVID) is the most common primary immunodeficiency, which affects antigen specific immunity.As the term says, its clinical manifestation is very miscellaneous, but distinctive is decreased level of immunoglobine's class IgG (under 3 g/l), IgA (under 0,05 g/l) and half of the patients have decreased level of IgM class and disorder in T.

The world's first wiki where authorship really matters. Due credit and reputation for authors [authorship tracking technology]. Imagine a global collaborative knowledge base for original thoughts [Nature Genetics] From Wikipedia, The Free Encyclopedia Common variable immunodeficiency (CVID) is an immune disorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin (Ig) types IgG, IgM and IgA Common Variable Immunodeficiency (CVID) is an immune disorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin (Ig) types IgG, IgM and IgA. It is thought to infect between 1 in 25,000 to 1 in 50,000 people worldwide

Common variable immunodeficiency - wikido

Children with common variable immunodeficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder. Viral infection is a very common cause of lymphoproliferative disorders. In children, the most common is believed to be The Epstein-Barr virus, which infects >90% of the world population, is also a common cause of these disorders, being. Common variable immunodeficiency (CVID) is a group of disorders characterized by low levels of a type of protein known as immunoglobulins (Ig). Because of low level of Ig, the immune system cannot make antibodies that fight bacteria, viruses or other toxins in the body

Common variable immunodeficiency - Libre Patholog

Almindelig variabel immundefekt ( CVID) er en immunforstyrrelse karakteriseret ved tilbagevendende infektioner og lave antistofniveauer, specifikt i immunglobulin (Ig) -typer IgG, IgM og IgA. Generelt inkluderer symptomer høj modtagelighed for fremmede angribere, kronisk lungesygdom og betændelse og infektion i mave-tarmkanalen. Imidlertid varierer symptomerne meget mellem mennesker Common variable immunodeficiency. Yleinen vaihteleva immuunipuutos ( CVID ) on immuunihäiriö, jolle on tunnusomaista toistuvat infektiot ja matalat vasta- ainetasot, erityisesti immunoglobuliinityyppien (Ig) IgG, IgM ja IgA kohdalla. Yleensä oireita ovat suuri alttius ulkomaisille hyökkääjille, krooninen keuhkosairaus sekä maha. Imunodeficiența variabilă comună ( CVID) este o tulburare imunitară caracterizată prin infecții recurente și niveluri scăzute de anticorpi, în special în tipurile de imunoglobulină (Ig) IgG, IgM și IgA. În general, simptomele includ susceptibilitate ridicată la invadatorii străini, boli pulmonare cronice și inflamații și infecții ale tractului gastro-intestinal Common variable immunodeficiency (CVID) is an antibody deficiency that leaves the immune system unable to defend against bacteria and viruses, resulting in recurrent and often severe infections primarily affecting the ears, sinuses, and respiratory tract (sinopulmonary infections) Common, Variable, Unclassified Immunodeficiency (Acquired Hypogammaglobulinemia) This designation includes the most common form of hypogammaglobulinemia diagnosed in adults

Common variable immune deficiency (CVID) is a disorder that impairs the immune system. People with CVID are highly susceptible to infection from foreign invaders such as bacteria, or more rarely, viruses and often develop recurrent infections, particularly in the lungs, sinuses, and ears. Pneumonia is common in people with CVID Common variable immunodeficiency (CVID) is a disorder that involves the following: (1) low levels of most or all of the immunoglobulin (Ig) classes, (2) a lack of B lymphocytes or plasma cells that are capable of producing antibodies, and (3) frequent bacterial infections Alternate ICD10s to consider coding instead or in additio

(See chapter titled Common Variable Immune Deficiency.) At the present time, it is not possible to determine which patients will have the transient type of deficiency and in which patients the deficiency may be permanent or the forerunner of a more wide-ranging immunodeficiency, such as CVID Common variable immunodeficiency disease is rare, but not terribly so (it affects about 1 in 50,000 people). A case would probably appear in the hospital during House's stay there. It is also the most common primary immunodeficiency disease Common variable immunodeficiency (CVID) (also known as Acquired hypogammaglobulinemia) is a group of 2030 primary immunodeficiencies (PIDs), which have a common set of symptoms (including hypogammaglobulinemia) but which have different underlying causes

Common variable immunodeficiency (CVID) is a cluster of nearly 150 primary immunodeficiencies or PIDs that are characterized by a common group of features that includes hypogammaglobulinemia but are caused by different underlying factors One example is common variable immunodeficiency (CVID) where multiple autoimmune diseases are seen, e.g., inflammatory bowel disease, autoimmune thrombocytopenia, and autoimmune thyroid disease. Familial hemophagocytic lymphohistiocytosis, an autosomal recessive primary immunodeficiency, is another example. Low blood levels of red blood cells, white blood cells, and platelets, rashes, lymph. Hizentra subcutaneous injection (for injection under the skin) is used to treat primary immunodeficiency diseases. This includes, but is not limited to, the humoral immune defect in congenital agammaglobulinemia, common variable immunodeficiency, X-linked agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies Common Variable Immunodeficiency Definition Common variable immunodeficiency is an immunodeficiency disorder characterized by a low level of antibodies. Patients with this disease are subject to recurring infections. Description Immunodeficiency means that the immune system is deficient in one or more of its components and is unable to respond. Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin. Immunol. Immunopathol. 56 (2): 239-48. PMID 2165880. ↑ Artac H, Kara R, Gokturk B, Reisli I (November 2013). Reduced CD19 expression and decreased memory B cell numbers in transient.

Common variable immunodeficiency disease House Wiki Fando

T-Cell Immunodeficiencies. T-cell deficiencies include (a) DiGeorge syndrome, (b) chronic mucocutaneous candidiasis, (c) transient hypogammaglobu-linemia of infancy, and (d) common, variable, unclassified immunodeficiency. Thymic aplasia (DiGeorge syndrome) The DiGeorge syndrome or thymic aplasia is a classic example of a pure T-cell deficiency Define common variable immunodeficiency. common variable immunodeficiency synonyms, common variable immunodeficiency pronunciation, common variable immunodeficiency translation, English dictionary definition of common variable immunodeficiency. n. pl. im·mu·no·de·fi·cien·cies An innate, acquired, or induced inability to develop a normal. Common variable immunodeficiency (CVID) is an immune disorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin (Ig) types IgG, IgM and IgA. Generally symptoms include high susceptibility to foreign invaders, chronic lung disease, and inflammation and infection of the gastrointestinal tract

Common-variabele immunodeficiency afgekort CVID, is een vorm van primaire immuundeficiëntie (PID) die wordt gedefinieerd als een immunologische dysfunctie die gewoonlijk wordt veroorzaakt door een genetische afwijking, al is in dit geval de oorzaak vaak niet gekend of te vinden. Het is de meest voorkomende vorm van PID, alhoewel de aandoening met een prevalentie van 1 op de 50.000 vooralsnog. Bloom Syndrome is inherited as an autosomal recessive inherited disorder. Most common manifestations of Bloom syndrome include followings: Growth deficiency of prenatal onset. Immunodeficiency. Café-au-lait spots or hypopigmented skin lesions. Excessive photosensitivity with facial lupus-like skin lesions

CVID (Common variable immune deficiency) namu.wiki Contáctenos Términos de uso Operado por umanle S.R.L. Hecho con <3 en Asunción, República del Paraguay. Su zona horaria es GMT Impulsado por the seed engine. CVID(シーブイアイディー) . 分類不能型免疫不全症 (Common variable immunodeficiency) - ICD-10_第3章:血液および造血器の疾患ならびに免疫機構の障害#(D80-D89) 免疫機構の障害; 完全かつ検証可能で不可逆的な解体 (Complete, Verifiable and Irreversible Dismantlement) 完全かつ検証可能で不可逆的な非核化 (Complete. Ironmouse has [Common Variable Immune Deficiency] (CVID), a disorder that impairs the immune system. People with CVID are highly susceptible to infection from foreign invaders such as bacteria and viruses and often develop recurrent infections. It is because of this that Mouse has no option but to remain indoors and bedridden Common variable immunodeficiency Articles Case Reports Symptoms Treatment, China. Common variable immunodeficiency (CVID) is a heterogeneous disorder involving immune dysfunction of B and T lymphocytes and Common Variable Immune Deficiency (CVID) is a frequently diagnosed immunodeficiency, especially in adults, characterized by low.

Common Variable Immunodeficiency - WikiLecture

Common variable immunodeficiency (CVID) is the commonest primary immunodeficiency involving all classes of antibody. It is a heterogeneous group of disorders and includes a range of phenotypes. Many patients are not diagnosed until early adulthood. Most patients show low levels of IgG and IgA, with near normal or 50% of normal levels of IgM and. Other Inherited Causes: Boys with X-linked immunodeficiency syndrome are at a higher risk of mortality associated with EBV infections, and are predisposed to develop a lymphoproliferative disorder or lymphoma. Children with common variable immune deficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder

Microtia - Causes, Symptoms, Treatment and PicturesTodd Reirden&#39;s wife Shelby Anderson Reirden (Bio, Wiki)

WikiGenes - Common Variable Immunodeficienc

What Is Immunoglobulin Replacement Therapy? There are several specific medical therapies available for people with PI involving antibody deficiencies. Antibody deficiencies account for more than 50% of the disorders. These illnesses, such as Common Variable Immune Deficiency (CVID), X-linked Agammaglobulinemia (XLA), and other disorders, are characterized by a lack of and/o Immunodeficiency, also known as immunocompromisation, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired (secondary) due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection and environmental factors, such as nutrition

Common variable immunodeficiency disease from interaction of Epstein-Barr virus with anti-seizure medication 18 Babies & Bathwater: Naomi Randolph: Small-cell lung cancer: 19 Kids: Mary Carroll: Thrombotic thrombocytopenic purpura: 20 Love Hurts: Harvey Park: Fulminating osteomyelitis: 21 Three Stories: The Farmer: Necrotizing fasciitis. (See chapter titled Common Variable Immune Deficiency.) At this time, it is not possible to determine which patients will have the transient type of subclass deficiency and which patients may later develop a more significant immunodeficiency. For these reasons, regular reevaluation of immunoglobulin levels and function, as well as IgG.

Common Variable Immunodeficiency (CVID) is rare immunodeficiency disorder characterized by recurrent infections in the lungs, sinuses or ears. The range and severity of symptoms and findings associated with CVI may vary from case to case. In some cases, individuals with CVID have an increased tendency to develop infections of the. Clips from Common Variable Immune Deficiency Overview Disease characteristics. Common variable immune deficiency (CVID) is characterized by humoral immune deficiency with onset after 24 months of age and usually in young adulthood, resulting in increased susceptibility to infections and diminished responses to protein and polysaccharide vaccines FDA-approved indications: Immune thrombocytopenic purpura. Kawasaki. Common variable immunodeficiency, primary immunodeficiency associated with humoral imunodeficiency. Kidney transplant with high antibody recipient or ABO incompatible donor. Chronic B-cell leukemia, stem cell transplantation. Off-label indications. TTP, HUS Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease and cancer Small intestinal bacterial overgrowth. Other causes include inherited immunodeficiency conditions, such as common variable immunodeficiency, IgA deficiency, and Autoimmunity

Common variable immunodeficiency - WikiMili, The Best

Talk:Common variable immunodeficiency - Wikipedi

  1. Chapel, H, Cunningham-Rundles, C. Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patient with these conditions. Br J Haematol. vol. 145.
  2. Infections of the mouth, eyes, and digestive tract are common. Thrush, a fungal infection of the mouth, may be an early sign of an immunodeficiency disorder.Sores may form in the mouth. People may have chronic gum disease and frequent ear and skin infections.Bacterial infections (for example, with staphylococci) may cause pus-filled sores to form (pyoderma)
  3. Type Description ; X-linked severe combined immunodeficiency: Most cases of SCID are due to mutations in the IL2RG gene encoding the common gamma chain (γ c) (CD132), a protein that is shared by the receptors for interleukins IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.These interleukins and their receptors are involved in the development and differentiation of T and B cells
  4. Welcome to the Jeffrey Modell Foundation's Global PI Village! When Jeffrey was diagnosed with Primary Immunodeficiency, he asked us to Do Something! And as an old friend of Jeffrey's and his family, I decided to run for Mayor to ensure that here in the Global Village, we live by his wishes every day

Common variable immunodeficiency

The resulting deficiency is one cause of severe combined immunodeficiency (SCID), particularly of autosomal recessive gene implies a high incidence of ADA-deficient severe combined immunodeficiency (SCID) in Somalia and a single, common understanding catalysis and immunodeficiency mutations. Science. 252 (5010): 1278-1284. doi:10.1126. Immune Deficiency Foundation 110 West Road, Suite 300 Towson, Maryland 21204 Directions. Ask IDF ©2020 Immune Deficiency Foundation. Designed by BackOffice Thinking. Immune Deficiency Foundation is a 501(c)(3) organization (EIN: 52-1214782 The Jeffrey Modell Foundation's Medical Academy takes great pride in supporting novel, cutting edge, and innovative research. Here, physicians, scientists, and. young investigators have the opportunity to apply for a variety of grants. The research grants are to enhance the quality of life, advance new treatments, and ultimately

Common variable immunodeficiency Genetic and Rare

Ochronosis - Causes, Symptoms, Diagnosis, Treatment and

Find a Haematologist. Get information including the doctor's education/training, practice information, affiliations and mor Type Description; X-linked severe combined immunodeficiency: Most cases of SCID are due to mutations in the IL2RG gene encoding the common gamma chain (γ c) (CD132), a protein that is shared by the receptors for interleukins IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.These interleukins and their receptors are involved in the development and differentiation of T and B cells Combined immunodeficiency — also called combined immune deficiency or CID — is a genetic condition of the immune system. It's known as a primary immunodeficiency. Children inherit the gene for CID from their parents. CID occurs when gene mutations cause defects in the immune system Agammaglobulinemia Genetic Diseases, X-Linked Immunologic Deficiency Syndromes IgG Deficiency Ecthyma Common Variable Immunodeficiency Arthritis, Juvenile Rheumatic Diseases Arthritis, Rheumatoid. Chemicals and Drugs 6. Protein-Tyrosine Kinases Immunoglobulin delta-Chains Receptors,. Common variable immunodeficiency. Am J Med Sci. 2001 Jan. 321(1):42-8. . Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients..

In a 6-year-old Moroccan boy, born of consanguineous parents, with common variable immunodeficiency-3 (CVID3; 613493), van Zelm et al. (2011) identified a homozygous c.156G-C transversion (c.156G-C, NM_001770.5) in exon 2 of the CD19 gene, resulting in a trp52-to-cys (W52C) substitution at a conserved residue in the D1 extracellular. Hyper IgM syndromes is a group of primary immune deficiency disorders characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic hypermutation. Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum Immunoglobulin M (IgM) levels and a considerable deficiency in Immunoglobulins G (IgG), A (IgA) and E. MyIgSource is committed to helping both you and your loved ones manage a life with primary immunodeficiency (PI). Learn more about what PI is, treatment for PI, and find a strong support community and other resources Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function normally. To be considered a primary immunodeficiency (PID), the cause of the immune deficiency must not be secondary in nature (i.e., caused by other disease, drug treatment, or environmental exposure to toxins). Most primary immunodeficiencies are genetic disorders; the majority. Variabel immunbrist (engelska: Common variable immunodeficiency (CVID)) är en paraplyterm för en heterogen grupp immunbristsjukdomar karakteriserade av antikroppsbrist (hypogammaglobulinemi). Plasmaceller, som är högt differentierade B-celler specialiserade på att producera antikroppar, saknas hos personer med variabel immunbrist, men antalet mogna B-celler brukar vara normalt vilket.

See: Main article: Role of psychological factors in autoimmune disorders Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body attacks its own cells. Today there are more than 40 human diseases classified as either definite or probable autoimmune diseases, and they affect 5% to 7% of the. Common variable immunodeficiency (CVID) refers to a grouping of antibody deficiencies that lack a more specific genetic or phenotypic classification. It is the immunodeficiency classification with the greatest number of constituents, likely because of the numerous ways in which antibody production can be impaired and the frequency in which.

Common variable immunodeficiency - Wikipedia - da

Schaffer AA, Salzer U, Hammarstrom L, Grimbacher B.Deconstructing common variable immunodeficiency by genetic analysis این صفحه آخرین‌بار در ‏۲۶ مارس ۲۰۲۰ ساعت ‏۰۰:۳۱ ویرایش شده‌است.. Autoimmune enteropathy is often found in patients with selective IgA deficiency, common variable immunodeficiency (CVID) and IPEX,3,4 but the role of NK cells remains undetermined.6,7 In our case report, patient initially presented with CD which was difficult to manage along with recurrent, opportunistic infections such as candidiasis and CMV disease

Common variable immunodeficiency - Wikipedia - fi

This page is based on the copyrighted Wikipedia article Immunodeficiency ; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License. You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA Patients with common variable immunodeficiency often show abnormal mitogenic responses, low gp39 expres-sion, and subnormal IL-2 release after T-cell mitogenic stimulation, suggesting that the ba-sis of the disease is lack of T-cell help She suffers from CVID (Common Variable Immune Deficiency), a genetic disorder she was born with that prevents her immune system from properly producing antibodies, and as a result she is bedridden for long periods of time. She requires plasma infusions on a weekly basis, though in 2021 she has admitted that she is getting better at walking. Quote Together with the Epstein-Barr virus, it caused common variable immunodeficiency disease, which causes a deficiency in T-cells, B-cells, immunoglobulin and antibodies. Dr. Dr. Chase points out he guessed the patient had an immunoglobulin deficiency earlier, but Dr. House rejected it based on the fact it is generally a childhood disease

This includes, but is not limited to, common variable immunodeficiency, X-linked agammaglobulinemia, congenital agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies. In the European Union it is indicated as replacement therapy in adults, children and adolescents (0-18 years) in D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells D83.8 Other common variable immunodeficiencies D83.9 Common variable immunodeficiency, unspecified D84 Other immunodeficiencies D84.0 Lymphocyte function antigen-1 [LFA-1] defect D84.1 Defects in the complement syste Current lab projects: 1) Understanding the molecular basis of TACI defects in Common Variable Immunodeficiency using in vitro and in vivo models 2) Development of T cell strategies to improve outcome following stem cell transplantation including genetic modification of T cells using suicide genes and generation of virus specific T cells 3. Immunodeficiency disorders, such as common variable immunodeficiency and, less often, HIV and AIDS. Allergic bronchopulmonary aspergillosis. This is an allergic reaction to a fungus called aspergillus. The reaction causes swelling in the airways. Disorders that affect cilia function, such as primary ciliary dyskinesia. Cilia are small, hair. These are common infections that an intact immune system can usually control but one that can turn serious if the immune system is suppressed. TNF-α inhibitors are associated with an increased risk of tuberculosis and fungal infections like histoplasmosis, Common variable immunodeficiency (CVID

Classification and external resources ICD 10 D83 ICD 9 279.0 Initial visibility: currently defaults to autocollapse To set this template's initial visibility, the |state= parameter may be used: |state=collapsed: {{Lymphoid and complement immunodeficiency|state=collapsed}} to show the template collapsed, i.e., hidden apart from its title bar |state=expanded: {{Lymphoid and complement immunodeficiency|state=expanded}} to show the template expanded, i.e. Palandri, F.; Agostini, C. et al. (Sep 2007). Association between sarcoidosis-like disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune system.. Sarcoidosis Vasc Diffuse Lung Dis 24 (2): 127-33. PMID 18496983 She is a passionate advocate for mental health awareness and suicide prevention, and is an active fighter against common variable immune deficiency disorder. In December 2016, Megan signed a deal with Amazon's Kindle Press for her Kindle Scout Winner, Court of Vampires, published January 31, 2016 Common variable immunodeficiency is the most common severe antibody deficiency affecting both children and adults. 5 It has a variable age of onset, usually occurring by the third decade, although there is often a significant delay between symptoms and diagnosis. These patients have hypogammaglobulinaemia (low IgG with low IgA and/or IgM), poor.

Common variable immunodeficiency - Wikipedia - ro

IgA deficiency and common variable immunodeficiency (CVID) feature similar B cell differentiation arrests, but it does not present the same lymphocyte subpopulation abnormalities. IgA-deficient patients may progress to panhypogammaglobulinemia characteristic of CVID. Selective IgA and CVID are found in the same family. Caus Isolated primary immunoglobulin M deficiency is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulins are normal. The immunodeficiency has been associated with some clinical disorders including recurrent infections, atopy, Bloom's syndrome, celiac disease, systemic lupus erythematosus and malignancy, but, surprisingly, SIgMD seems. X-linked agammaglobulinemia (XLA) is a rare genetic disorder discovered in 1952 that affects the body's ability to fight infection.As the form of agammaglobulinemia that is X-linked, it is much more common in males.In people with XLA, the white blood cell formation process does not generate mature B cells, which manifests as a complete or near-complete lack of proteins called gamma globulins.

Common Variable Immunodeficiency Symptoms, Diagnosis

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time. 106P- Common Variable Immunodeficiency, Isolated IgA Deficiency, Hyper-IgM and DiGeorge Syndrome Hypogammaglobulinemia or Common Variable Immunodeficiency (CVID) CVID is the second most common cause of hypogammaglobulinemia and affects both sexes equally. The incidence is about 1 in 50,000 people. In most patients there is a reduced amount of the immunoglobulins IgG, IgA, and IgM in the blood. It is an immune deficiency disorder that can.

Common, Variable, Unclassified Immunodeficiency (Acquired

Common variable immune deficiency: MedlinePlus Genetic

Inherited Immunodeficiency Syndromes. Generalized lymphadenopathy often is characteristic of inherited immunodeficiency syndromes (e.g., Wiskott-Aldrich syndrome, common variable immunodeficiency) (see Box 16.4). Detection of dysregulated lymphoproliferation in these patients with underlying chronic generalized lymphadenopathy can be difficult Collagen-vascular diseases, lymphoproliferative diseases, common variable immunodeficiency, chronic biliary disease, drugs: Hepatoportal sclerosis: Missing portal veins, herniation of portal veins into sinusoids: Collagen-vascular diseases, common variable immunodeficiency, drugs: Portal vein thrombosis: Missing portal veins, arterialization of. immunodeficiency, common variable, type 4 A primary immunodeficiency (OMIM:613494) characterised by antibody deficiency, hypogammaglobulinaemia, recurrent bacterial infections and an inability to mount an antibody response to antigens, due to a failure of B-cell differentiation and impaired secretion of immunoglobulins Common variable immunodeficiency (CVID): CVID is the most common symptomatic primary immunodeficiency in adults. Symptoms of CVID are usually mixed and nonspecific. It commonly occurs among children (1-5 years) and young adults (18-25 years).